Iridoid constituents from the male flower of Eucommia ulmoides and their promotion proliferation on ESF-1

  • 文献类型:   Article
  • 作  者:   DING YX, LI Q, ZHANG H, KIM YH, DOU DQ
  • 关键词:   eucommia ulmoide, iridoid, promotion proliferation, esf1
  • 出版物名称:   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
  • ISSN:   1028-6020 EI 1477-2213
  • 通讯作者地址:   Chungnam Natl Univ
  • 被引频次:   1
  • DOI:   10.1080/10286020.2015.1039999
  • 出版年:   2015
  • 研究对象:   药化成分
  • 研究主题:   分离合成测定

▎ 摘  要

Four new iridoids (1, 2, 12, and 13), together with nine known iridoids (3-11), were isolated from the male flowers of Eucommia ulmoides Oliver and were characterized as 3-methoxyartselawnin C (1), 6-hydroxyl-1,3-dimethoxyartsclaenin III (2), 3,4-dihydro-3-ethoxyasperuloside (12) and 3,4-dihydro-3-ethoxydesacetylasperuloside (13) by extensive analyses of their 1D and 2D NMR spectroscopy and mass spectra. All of the isolated compounds were assayed for the promoting proliferation of skin fibroblasts cell (ESF-1) and compounds 4 and 7 (5M) significantly stimulated the proliferation of ESF-1 cells.

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